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Cayman Chemical a Cayman Pharma - nyní u SpinChem

Spinchem s.r.o. se stal distributorem Cayman Chemical a Cayman Pharma pro Českou a Slovenskou Republiku. 

 

Nový 2'3'-cGAMP ELISA Kit od Cayman Chemical

DESCRIPTION
Features
Measure 2'3'-cGAMP in cell lysates
Assay 24 samples in triplicate or 36 samples in duplicate
Lower limit of detection (LLOD) is 9.6 pg/ml (0.01 pmol/ml)
Run with overnight or 2-hour incubation protocols without compromising sensitivity
Monitor the kinetics of 2'3'-cGAMP formation and hydrolysis in a biological setting
Identify compounds that modulate cGAS activity
Synonyms
2'3'-cGAMP EIA Kit
2'3'-Cyclic GMP-AMP
Guanosine-Adenosine 2',3'-cyclic monophosphate
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects the presence of nucleic acids in the cytosol of mammalian cells as an indicator of bacterial or viral infection.1 cGAS catalyzes the synthesis of a second messenger, 2’3’-cGAMP, from cytosolic ATP and GTP in response to dsDNA binding. 2’3’-cGAMP then binds tightly to the adaptor protein STING (stimulator of interferon genes), resulting in the recruitment of TBK1 and subsequent IRF3 phosphorylation.2 IRF3 induces the transcription and translation type I interferon, a potent antiviral cytokine.3 Activation of cGAS and the production of 2’3’-cGAMP are important in host defense, but also may play role in autoimmune or inflammatory diseases. Modulation of cGAS activity, with subsequent inhibition of induction of 2’3’-cGAMP formation is an active target of pharmacological intervention.4

 

more info at https://www.caymanchem.com/product/501700

 

Citrullination Research Products by Cayman Chemical

Vimentin (human recombinant)
Item № 11234, Purity ≥90% estimated by SDS-PAGE
https://www.caymanchem.com/product/11234

Vimentin (human recombinant)
Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells. Each vimentin monomer contains a central α-helix that facilitates formation of the coil-coil dimer required for vimentin filament assembly. Vimentin is attached to nuclei, endoplasmic reticulum, and mitochondria, and has a role in positioning organelles in the cytosol. It regulates glial morphology, facilitates motility and directional migration of fibroblasts, and is critical to mechanotransduction of shear stress and maintenance of vascular endothelial integrity. Vimentin controls transport of LDL-derived cholesterol from lysosomes to esterification sites. It is an aggresome component, forming a cage-like structure around aggregated, undegraded proteins at the microtubule organizing center. Vimentin is subject to citrullination under high calcium concentrations, which can occur during macrophage apoptosis, and citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs). ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.

Citrullinated Vimentin (human recombinant)
Item № 21942, Purity ≥55 %
https://www.caymanchem.com/product/21942

Citrullinated Vimentin (human recombinant)
Vimentin is subject to citrullination by peptidyl arginine deiminase 2 (PAD2; Item No. 10785) under high calcium concentrations, which can occur during macrophage apoptosis. Citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs). ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.

Citrullinated Vimentin Monoclonal Antibody (Clone 12G11)
Item № 22054
https://www.caymanchem.com/product/22054

Citrullinated Vimentin Monoclonal Antibody (Clone 12G11)
Cayman's Citrullinated Vimentin Monoclonal Antibody (Clone 12G11) can be used for Western blot and ELISA applications. The antibody recognizes citrullinated vimentin at ~54 kDa from human samples.

Proteiny

https://www.caymanchem.com/Search?q=citrullination&fq=raptas%3ARAP000073

Protilátky

https://www.caymanchem.com/Search?q=citrullination&fq=raptas%3ARAP000002

 

Změna cen

Od. 1.1.v každém roce většina námi distribuovaných firem upravuje ceny. Firma Santa Cruz mění ceny v průběhu roku. Do změny cen se rovnež promítá měnící se pohyb kurzu a změna výše DPH v ČR.